- 中文名称
5-Hydroxytryptamine Receptor 1B (胞外)抗体
- 英文名字
- 5-Hydroxytryptamine Receptor 1B (extracellular) Antibody
- 供应商
- Abgent
- 产品货号
- A-AW5541
- 产品报价
- ￥3250/200 ul
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
- Serotonin (5-hydroxytryptamine, 5-HT) plays unequivocally a most important role in the normal physiology amongst higher eukaryotes, as do most neurotransmitters. The physiological roles of serotonin and its receptors range from appetite, regulation of the circadian rthythm, sexual behavior, memory and nociception. Serotonin is also involved in migraine and some psychiatric diseases such as depression anxiety and aggression1. Serotonin and its receptors also have an influence on the cardiovascular, pulmonary, gastrointestinal (GI) and genitourinary systems2.
To date, some fifteen serotonin receptors have been cloned and grouped into seven families (5-HT1-5-HT7) based on their signaling mechanisms. The 5-HT1 receptor class comprises 5 different receptors with ranging homology. Apart from 5-HT3, all serotonin receptors belong to the G-Protein Coupled Receptor superfamily and therefore span the membrane seven times3.
The 5-Hydroxytryptamine Receptor 1B (5-HT1B) is involved in several physiological behaviors and psychiatric disease, including locomotor activity, drug abuse reinforcement, migraine, anxiety states and aggressive behaviors1.
Pharmacological studies suggest that 5-HT1B is expressed by both serotonergic and non-serotonergic neurons. In the nervous system, this receptor is located in the axon terminal of the plasma membrane of unmyelinated axons. It is predominantly localized on pre-synaptic membranes. Signal transduction studies of the receptor indicate that this receptor is coupled negatively to adenylyl cyclase as its activation induces a decrease in adenylyl cyclase activity1.
Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of human 5-Hydroxytryptamine Receptor 1B (5-HT1B). Anti-5-Hydroxytryptamine Receptor 1B (extracellular) antibody (#AG1011) can be used for western blot analysis. It has been designed to recognize 5-Hydroxytryptamine Receptor 1B from human, rat and mouse samples.
- 应用类型
- WB
- 免疫原
- P28222
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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