This gene encodes a protein that binds to the C-terminus
of adenovirus E1A proteins. This phosphoprotein is a
transcriptional repressor and may play a role during cellular
proliferation. This protein and the product of a second closely
related gene, CTBP2, can dimerize. Both proteins can also interact
with a polycomb group protein complex which participates in
regulation of gene expression during development. Alternative
splicing of transcripts from this gene results in multiple
transcript variants.
