The protein encoded by this gene belongs to the
ubiquitin-conjugating enzyme family. This protein interacts with
RING finger proteins, and it can ubiquitinate huntingtin, the gene
product for Huntington's disease. Known functions for this protein
include a role in aggregate formation of expanded polyglutamine
proteins and the suppression of apoptosis in polyglutamine
diseases, a role in the dislocation of newly synthesized MHC class
I heavy chains from the endoplasmic reticulum, and involvement in
foam cell formation. Multiple transcript variants encoding
different isoforms have been identified for this gene. [provided by
RefSeq].
