- 中文名称
F13B抗体(N端)
- 英文名字
- F13B Antibody (N-term)
- 供应商
- Abgent
- 产品货号
- A-AP20162a
- 产品报价
- ￥2310/400 ul
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- This gene encodes coagulation factor XIII B subunit.
Coagulation factor XIII is the last zymogen to become activated in
the blood coagulation cascade. Plasma factor XIII is a
heterotetramer composed of 2 A subunits and 2 B subunits. The A
subunits have catalytic function, and the B subunits do not have
enzymatic activity and may serve as a plasma carrier molecules.
Platelet factor XIII is comprised only of 2 A subunits, which are
identical to those of plasma origin. Upon activation by the
cleavage of the activation peptide by thrombin and in the presence
of calcium ion, the plasma factor XIII dissociates its B subunits
and yields the same active enzyme, factor XIIIa, as platelet factor
XIII. This enzyme acts as a transglutaminase to catalyze the
formation of gamma-glutamyl-epsilon-lysine crosslinking between
fibrin molecules, thus stabilizing the fibrin clot. Factor XIII
deficiency is classified into two categories: type I deficiency,
characterized by the lack of both the A and B subunits; and type II
deficiency, characterized by the lack of the A subunit alone.
These defects can result in a lifelong bleeding tendency, defective
wound healing, and habitual abortion.
- 应用类型
- WB
- 免疫原
- P05160
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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