The protein encoded by this gene belongs to the class II
cytokine receptor family. This protein forms a receptor complex
with interleukine 10 receptor, beta (IL10RB). The receptor complex
has been shown to interact with three closely related cytokines,
including interleukin 28A (IL28A), interleukin 28B (IL28B), and
interleukin 29 (IL29). The expression of all three cytokines can be
induced by viral infection. The cells overexpressing this protein
have been found to have enhanced responses to IL28A and IL29, but
decreased response to IL28B. Three alternatively spliced transcript
variants encoding distinct isoforms have been reported. [provided
by RefSeq].
