The protein encoded by this gene is a cyclic nucleotide
phosphodiesterase (PDE) that catalyzes the hydrolysis of the second
messenger cAMP. The encoded protein, which does not hydrolyze cGMP,
is resistant to several PDE inhibitors. Defects in this gene are a
cause of autosomal dominant striatal degeneration (ADSD). Several
transcript variants encoding different isoforms have been found for
this gene.
