Nonvoltage-gated, amiloride-sensitive, sodium channels
control fluid and electrolyte transport across epithelia in many
organs. These channels are heteromeric complexes consisting of 3
subunits: alpha, beta, and gamma. This gene encodes the beta
subunit, and mutations in this gene have been associated with
pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome.
