Cancer-associated chromosomal changes often involve
regions containing fragile sites. This gene maps to a commom
fragile site on chromosome 7q31.2 designated FRA7G. This gene is
similar to mouse Testin, a testosterone-responsive gene encoding a
Sertoli cell secretory protein containing three LIM domains. LIM
domains are double zinc-finger motifs that mediate protein-protein
interactions between transcription factors, cytoskeletal proteins
and signaling proteins. Multiple protein isoforms are encoded by
transcript variants of this gene.
