HERC3 belongs to the HERC family of ubiquitin ligases, all
of which contain a HECT domain and at least 1 RCC1 (MIM
179710)-like domain (RLD). The 350-amino acid HECT domain is
predicted to catalyze the formation of a thioester with ubiquitin
before transferring it to a substrate, and the RLD is predicted to
act as a guanine nucleotide exchange factor for small G proteins
(Hochrainer et al., 2005 [PubMed 15676274]).
