This gene encodes a CXC chemokine receptor specific for
stromal cell-derived factor-1. The protein has 7 transmembrane
regions and is located on the cell surface. It acts with the CD4
protein to support HIV entry into cells and is also highly
expressed in breast cancer cells. Mutations in this gene have been
associated with WHIM (warts, hypogammaglobulinemia, infections, and
myelokathexis) syndrome. Alternate transcriptional splice variants,
encoding different isoforms, have been characterized. [provided by
RefSeq].
