This gene encodes a G-protein coupled receptor that binds
non-sulfated members of the cholecystokinin (CCK) family of peptide
hormones. This receptor is a major physiologic mediator of
pancreatic enzyme secretion and smooth muscle contraction of the
gallbladder and stomach. In the central and peripheral nervous
system this receptor regulates satiety and the release of
beta-endorphin and dopamine.
