The protein encoded by this gene is a type I transmembrane
protein that localizes to the endocytic pathway. This protein
contains a RING zinc-finger motif and has been shown to possess E3
ubiquitin ligase activity. Expression of this gene in retrovirally
transduced T cell hybridoma significantly inhibits
activation-induced IL2 and IL4 cytokine production. Induced
expression of this gene was observed in anergic CD4(+) T cells,
which suggested a role in the induction of anergic phenotype.
Alternatively spliced transcript variants encoding distinct
isoforms have been reported.
