Members of the nuclear hormone receptor family, such as
NR2C2, act as ligand-activated transcription factors. The proteins
have an N-terminal transactivation domain, a central DNA-binding
domain with 2 zinc fingers, and a ligand-binding domain at the C
terminus. The activated receptor/ligand complex is translocated to
the nucleus where it binds to hormone response elements of target
genes (Yoshikawa et al., 1996 [PubMed 8661150]).
