This gene encodes a tumor suppressor protein that acts as
an antagonist of the Wnt signaling pathway. It is also involved in
other processes including cell migration and adhesion,
transcriptional activation, and apoptosis. Defects in this gene
cause familial adenomatous polyposis (FAP), an autosomal dominant
pre-malignant disease that usually progresses to malignancy.
Disease-associated mutations tend to be clustered in a small region
designated the mutation cluster region (MCR) and result in a
truncated protein product.
