This gene encodes a transmembrane protein with two
extracellular Kunitz domains that inhibits a variety of serine
proteases. The protein inhibits HGF activator which prevents the
formation of active hepatocyte growth factor. This gene is a
putative tumor suppressor, and mutations in this gene result in
congenital sodium diarrhea. Multiple transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq].
