The protein encoded by this gene is member of the GAP1
family of GTPase-activating proteins. The gene product stimulates
the GTPase activity of normal RAS p21 but not its oncogenic
counterpart. Acting as a suppressor of RAS function, the protein
enhances the weak intrinsic GTPase activity of RAS proteins
resulting in the inactive GDP-bound form of RAS, thereby allowing
control of cellular proliferation and differentiation. This family
member is an inositol 1,3,4,5-tetrakisphosphate-binding protein,
like the closely related RAS p21 protein activator 2. The two
family members have distinct pleckstrin-homology domains, with this
particular member having a domain consistent with its localization
to the plasma membrane.
