This gene is a member of a phylogenetically conserved
family of genes that share a common DNA-binding domain, the T-box.
T-box genes encode transcription factors involved in the regulation
of developmental processes. This gene is the human homolog of mouse
Tbx4, which is closely linked to Tbx2 on mouse chromosome 11.
Similarly this gene, like TBX2, maps to human chromosome 17.
Expression studies in mouse and chicken show that Tbx4 is expressed
in developing hindlimb, but not in forelimb buds, suggesting a role
for this gene in regulating limb development and specification of
limb identity.
