The protein encoded by this gene catalyzes the
isomerization of mannose 6-phosphate to mannose 1-phosphate, which
is a precursor to GDP-mannose necessary for the synthesis of
dolichol-P-oligosaccharides. Mutations in this gene have been shown
to cause defects in glycoprotein biosynthesis, which manifests as
carbohydrate-deficient glycoprotein syndrome type I. [provided by
RefSeq].
