The protein encoded by this gene contains a RING finger
motif, which is most closely related to those of polycomb group
(PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to
form protein complexes and function as transcription repressors.
This protein has been shown to interact with some PcG proteins and
act as a transcription repressor. The activity of this protein is
found to be regulated by cell cycle dependent phosphorylation.
Alternatively spliced transcript variants encoding different
isoforms have been identified.
