This gene encodes a cytokine receptor that specifically
binds interleukin 15 (IL15) with high affinity. The receptors of
IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This
forms the basis of many overlapping biological activities of IL15
and IL2. The protein encoded by this gene is structurally related
to IL2R alpha, an additional IL2-specific alpha subunit necessary
for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of
binding IL15 with high affinity independent of other subunits,
which suggests distinct roles between IL15 and IL2. This receptor
is reported to enhance cell proliferation and expression of
apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively
spliced transcript variants of this gene have been reported.
