This gene belongs to the motin family of angiostatin
binding proteins characterized by conserved coiled-coil domains and
C-terminal PDZ binding motifs. The encoded protein is expressed
predominantly in endothelial cells of capillaries as well as larger
vessels of the placenta where it may mediate the inhibitory effect
of angiostatin on tube formation and the migration of endothelial
cells toward growth factors during the formation of new blood
vessels. Alternative splicing results in multiple transcript
variants encoding different isoforms.
