The protein encoded by this gene contains a RING finger
domain, a motif known to be involved in protein-protein and
protein-DNA interactions. The mouse counterpart of this gene
(Rnf111/arkadia) has been shown to genetically interact with the
transforming growth factor (TGF) beta-like factor Nodal, and act as
a modulator of the nodal signaling cascade, which is essential for
the induction of mesoderm during embryonic development. [provided
by RefSeq].
