Cyclic nucleotides are important second messengers that
regulate and mediate a number of cellular responses to
extracellular signals, such as hormones, light, and
neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs)
regulate the cellular concentrations of cyclic nucleotides and
thereby play a role in signal transduction. PDE4C is a class IV
cAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed
8009369]).
