CHMP5 belongs to the chromatin-modifying protein/charged
multivesicular body protein (CHMP) family. These proteins are
components of ESCRT-III (endosomal sorting complex required for
transport III), a complex involved in degradation of surface
receptor proteins and formation of endocytic multivesicular bodies
(MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular
distributions, and one such CHMP, CHMP1A (MIM 164010), is required
for both MVB formation and regulation of cell cycle progression
(Tsang et al., 2006 [PubMed 16730941]).
