This gene encodes a protein that may be involved in the
degradation of G proteins via the ubiquitin-dependent proteasome
pathway. The encoded protein binds to members of subfamily A of the
regulator of the G-protein signaling (RGS) family through an
N-terminal leucine-rich region. This protein also has a central
RING finger-like domain and E3 ubiquitin ligase activity. This
protein is highly conserved from flies to humans. Defects in this
gene may cause the autosomal recessive, infantile malignant form of
osteopetrosis.
