- 中文名称
TFE3抗体(N端)
- 英文名字
- TFE3 Antibody (N-term)
- 供应商
- Abgent
- 产品货号
- A-AP18316A
- 产品报价
- ￥2600/400 ul
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
- The microphthalmia transcription factor/transcription
factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper
(bHLH-Zip) transcription factors includes four family members:
MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene
activates transcription through binding to the muE3 motif of the
immunoglobulin heavy-chain enhancer. The TFEC protein forms
heterodimers with the TEF3 protein and inhibits TFE3-dependent
transcription activation. The TEF3 protein interacts with
transcription regulators such as E2F3, SMAD3, and LEF-1, and is
involved in TGF-beta-induced transcription, playing important roles
in cell growth, proliferation, and osteoclast and macrophage
differentiation. The TFE3 protein also activates hepatic IRS-2
gene, and induces hexokinase II (HK2) and insulin-induced gene 1
(INSIG1); it participates in insulin signaling and could be a
therapeutic target for diabetes. This gene is also involved in
chromosomal translocations, resulting in different fusion gene
products in papillary renal cell carcinomas and alveolar soft part
sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO
(p54nrb)-TFE3 and ASPL-TFE3.
- 应用类型
- WB
- 免疫原
- P19532
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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