The protein encoded by this gene mediates transcriptional
control by interaction with the activation function 2 (AF2) region
of several nuclear receptors, including the estrogen, retinoic
acid, and vitamin D3 receptors. The protein localizes to nuclear
bodies and is thought to associate with chromatin and
heterochromatin-associated factors. The protein is a member of the
tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 -
and a coiled-coil region. Two alternatively spliced transcript
variants encoding different isoforms have been described for this
gene.
