The protein encoded by this gene is a secreted,
extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif
and calcium-binding EGF-like domains. It promotes adhesion of
endothelial cells through interaction of integrins and the RGD
motif. It is prominently expressed in developing arteries but less
so in adult vessels. However, its expression is reinduced in
balloon-injured vessels and atherosclerotic lesions, notably in
intimal vascular smooth muscle cells and endothelial cells.
Therefore, the protein encoded by this gene may play a role in
vascular development and remodeling. Defects in this gene are a
cause of autosomal dominant cutis laxa, autosomal recessive cutis
laxa type I (CL type I), and age-related macular degeneration type
3 (ARMD3).
