- 中文名称
ALPL抗体
- 英文名字
- ALPL Antibody
- 供应商
- Abgent
- 产品货号
- A-AO1683a
- 产品报价
- ￥3850/0.1mg
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
- There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.
- 应用类型
- WB
- 免疫原
- P05186
- 来源宿主
- С
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
-
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