REDD1, Regulated in Development and DNA damage responses 1, is induced
by hypoxia, cell stress, and apoptosis. Reduced REDD
1 levels can sensitize cells towards apoptosis,
where elevated levels of REDD1 induced by hypoxia c
an desensitize cells to apoptotic stimuli (Schwarzer
et al, 2005). REDD1 has a crucial role in inhibiting mammalian rapamycin complex 1 (mTORC1) signaling
during hypoxic stress (Katiyar et al, 2009). It has
been shown that the rapid degradation of REDD1 is
mediated by the CUL4A
