Syntaxins are a family of proteins
involved in the docking of synaptic
vesicles with the plasma membrane. Syntaxin, along with synaptobrevin and SNAP-25, forms
the SNARE complex which mediates synaptic vesicle fusion and exocytosis. Binding of
Munc18-1 to the N-terminus of syntaxin 1 has
been demonstrated to be essential for exocytic
membrane fusion (Khvotchev et al., 2007). Decreased levels of phosphorylated syntaxin 1 in
the prefrontal cortex have recently been correlated with schizophrenia (Castillo et al., 2010).
