Phosphatidylethanolamine binding protein (PEBP), also known as Raf
kinase inhibitory protein (RKIP) is a highly conserved multifunctional protein that modulates the
Raf/MAPK signaling cascade and has been implicated as a suppressor of metastatic cancer
(Trakul N et al., 2005). PEBP has been shown to not only inhibit cell proliferation but also to
induce differentiation of human keratinocytes (Yamazaki et al., 2004). Dysregulation of calpain
activity results in cellular degeneration in conditions such as Alzheimer
