This gene encodes the D4 subtype of the dopamine receptor.
The D4 subtype is a G-protein coupled receptor which inhibits
adenylyl cyclase. It is a target for drugs which treat
schizophrenia and Parkinson disease. Mutations in this gene have
been associated with various behavioral phenotypes, including
autonomic nervous system dysfunction, attention
deficit/hyperactivity disorder, and the personality trait of
novelty seeking. This gene contains a polymorphic number (2-10
copies) of tandem 48 nt repeats; the sequence shown contains four
repeats.
