This gene encodes a major cytoplasmic protein which is the
only known constituent common to submembranous plaques of both
desmosomes and intermediate junctions. This protein forms distinct
complexes with cadherins and desmosomal cadherins and is a member
of the catenin family since it contains a distinct repeating amino
acid motif called the armadillo repeat. Mutation in this gene has
been associated with Naxos disease. Alternative splicing occurs in
this gene; however, not all transcripts have been fully described.
