The protein encoded by this gene is a transferase, which
catalyzes conversion of hypoxanthine to inosine monophosphate and
guanine to guanosine monophosphate via transfer of the
5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This
enzyme plays a central role in the generation of purine nucleotides
through the purine salvage pathway. Mutations in this gene result
in Lesch-Nyhan syndrome or gout.
