This gene encodes a protein that belongs to the
non-histone chromosomal high mobility group (HMG) protein family.
HMG proteins function as architectural factors and are essential
components of the enhancesome. This protein contains structural
DNA-binding domains and may act as a transcriptional regulating
factor. Identification of the deletion, amplification, and
rearrangement of this gene that are associated with myxoid
liposarcoma suggests a role in adipogenesis and mesenchymal
differentiation. A gene knock out study of the mouse counterpart
demonstrated that this gene is involved in diet-induced obesity.
Alternate transcriptional splice variants, encoding different
isoforms, have been characterized.
