This gene is imprinted, with preferential expression of
the maternal allele. The encoded protein is a tight-binding, strong
inhibitor of several G1 cyclin/Cdk complexes and a negative
regulator of cell proliferation. Mutations in this gene are
implicated in sporadic cancers and Beckwith-Wiedemann syndorome,
suggesting that this gene is a tumor suppressor candidate. Three
transcript variants encoding two different isoforms have been found
for this gene.
