This gene encodes a member of the serine/threonine protein
kinase family. This kinase contains a leucine-zipper domain and is
predominately expressed in neuronal cells. The phosphorylation
state of this kinase in synaptic terminals was shown to be
regulated by membrane depolarization via calcineurin. This kinase
forms heterodimers with leucine zipper containing transcription
factors, such as cAMP responsive element binding protein (CREB) and
MYC, and thus may play a regulatory role in PKA or retinoic acid
induced neuronal differentiation. Alternatively spliced transcript
variants encoding different proteins have been described.[provided
by RefSeq].
