This gene encodes the integrin alpha X chain protein.
Integrins are heterodimeric integral membrane proteins composed of
an alpha chain and a beta chain. This protein combines with the
beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred
to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2
complex seems to overlap the properties of the alpha M beta 2
integrin in the adherence of neutrophils and monocytes to
stimulated endothelium cells, and in the phagocytosis of complement
coated particles.
