- 中文名称
Involucrin抗体[克隆SY5]
- 英文名字
- Involucrin Antibody [Clone SY5]
- 供应商
- Abgent
- 产品货号
- A-AH10332
- 产品报价
- ￥2870/100 ug
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- It recognizes a protein of 66kDa-170kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120kDa protein. It stains the involucrin in a variety of sizes: 170kDa in MCF-7 cells, a doublet of ~115kDa and 150kDa in gorilla and owl monkey, 66kDa in dog, and a doublet of 105kDa in pig. Its epitope maps between codon 421-568 of human involucrin. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.
- 应用类型
- ELISA
- 免疫原
- P07476
- 来源宿主
- С
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
-
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