- 中文名称
FOXP3抗体[克隆3G3]
- 英文名字
- FOXP3 Antibody [Clone 3G3]
- 供应商
- Abgent
- 产品货号
- A-AH10040
- 产品报价
- ￥2870/100 ug
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
- Recognizes a protein of 47-55kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion (amino acids 2-136) of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.
- 应用类型
- ELISA
- 免疫原
- Q9BZS1
- 来源宿主
- С
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
-
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