- 中文名称
TRPM7抗体
- 英文名字
- TRPM7 Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1448
- 产品报价
- ￥3025/25 ul
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1 The TRP channels have putative six-transmembrane domains (TM) with a pore domain between the fifth and the six TM, and all assemble as tetramers. Both the N- and the C-terminus of all TRPs are intracellular.3
According to IUPHAR the TRP family comprises of three main subfamilies on the basis of sequence homology; TRPC (canonical), TRPV (vanilloid) and TRPM (melastatin). To date, three extra subfamilies are also considered to belong to the TRP family; the TRPA, TRPML, and the TRPP.1-4
The TRPM subfamily consists of eight members, TRPM1 to TRPM8, which also can be further subdivided into four subgroups based on their sequence homology: (1)TRPM1 and TRPM3 (2) TRPM6 and TRPM7 (3) TRPM4 and TRPM5 (4) TRPM2 and TRPM8.5
TRPM7 and TRPM6 are involved in Mg2+ homeostasis and are unique among the TRP family members, possessing a functional kinase domain at their C-terminus.6,7 Although the kinase is not necessary to the function of the channel it may have a role in modulating the activation of the channel.7 Recent work demonstrated that TRPM7 is a critical mediator of anoxic cell death.7,8
Alomone Labs is pleased to offer a highly specific antibody directed against an intracellular epitope of human TRPM7. The Anti-TRPM7 antibody (#AG1448) can be used in western blot analysis, immunocytochemical and immunohistochemical applications. It has been designed to recognize TRPM7 from human, rat and mouse samples.
- 应用类型
- WB
- 免疫原
- Q96QT4
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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