- 中文名称
KCC1抗体
- 英文名字
- KCC1 Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1425
- 产品报价
- ￥3025/25 ul
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
Potassium chloride cotransporters (KCCs) are members of cation chloride cotransporter gene superfamily (Slc12 family). This family consists of sodium potassium two chloride cotransporter 1 (NKCC1) and 2 (NKCC2), sodium chloride cotransporte (NCC) and KCCs1. All of these transporters mediate electroneutral transport of cations coupled with one or two Cl- and contribute to regulation of cell volume and homeostasis of intracellular Cl- concentration. KCCs extrude one K+ with one Cl- from intracellular space to the extracellular space by using the chemical gradient of K+ as the driving force of Cl- extrusion2.
Four KCC isofroms (KCC1, KCC2, KCC3 and KCC4) have been identified in mammalian species 3. K-Cl cotransporters regulate neuronal and glial electrochemical equilibrium potential for Cl-, and so can determine the excitatory or inhibitory influences of GABA- and glycine-gated Cl- channels4. KCC1 is a member of the cation-chloride cotransporter (CCC) superfamily of proteins, as with all CCC proteins, KCC1 is an integral membrane protein with 12 transmembrane domains and both N- and C-terminal cytoplasmic domains 5. KCC1 is ubiquitously expressed6.
K-Cl cotransport activity is elevated in red blood cells of individuals with sickle cell disease, thalassemia, and diseases associated with other mutant Hb. Human erythrocytes from individuals with the reticulocytotic anemic states of sickle cell disease, Hb SC disease, and β-thalassemia intermedia exhibit uniformly elevated KCC1-like immunoreactivity compared with normal AA erythrocytes 7.
- 应用类型
- WB
- 免疫原
- Q63632
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
-
