- 中文名称
Orexin Receptor 1抗体
- 英文名字
- Orexin Receptor 1 Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1413
- 产品报价
- ￥3025/25 ul
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- Orexin Receptor 1 (OX1R) (also known as hypocretin receptor 1) is one of two receptors that recognize the peptide neurotransmitters orexin A and orexin B.1 Orexin A and B are 33 and 28 amino acids in length, respectively, and are derived from a common precursor termed prepro-orexin.
OX1R binds orexin A with greater affinity than orexin B (a one order of magnitude difference), while OX2R binds both ligands with similar affinities.2,3
Both OX1R and OX2R belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.
OX1R is thought to transmit signals through the Ga11 class of G proteins, resulting in the activation of phospholipase C with subsequent triggering of the phosphatidylinositol cascade and an influx of extracellular Ca2+, probably through transient receptor potential (TRP) channels.2,3
The physiological functions of the orexin system (OX1R, OX2R, and their ligands) have been a matter of intense research in the last few years.
OX1R is expressed in both the central nervous system and peripheral locations such as gastrointestinal tissues, pancreas, and testis.2 It appears to be involved in the regulation of feeding behavior in rodents since an OX1R antagonist is able to inhibit baseline feeding.2,3
The orexin system has been shown to be involved in the regulation of sleep and wakefulness states and OX1R knockout mice show defects in the regulation of rapid eye movement (REM) sleep, among other phenotypic alterations.4 In addition, the orexin system is involved in regulating autonomic functions such as blood pressure and heart rate, as well as in mechanisms that regulate the reward response in the brain.4
Alomone Labs is pleased to offer a highly specific antibody directed against an epitope located in the 3rd intracellular loop of rat Orexin Receptor 1. Anti-Orexin Receptor 1 antibody (#AG1413) can be used in Western blot, immunocytochemical, and immunohistochemical applications and recognizes OX1R from rat, mouse, and human samples.
- 应用类型
- WB
- 免疫原
- P56718
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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