- 中文名称
Aquaporin 11 (胞外)抗体
- 英文名字
- Aquaporin 11 (extracellular) Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1395
- 产品报价
- ￥3025/25 ul
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
The aquaporins (AQP), also known as the major intrinsic protein superfamily (MIP), are a family of integral membrane proteins. In mammals, 13 aquaporins were described (AQP0 – AQP12). Aquaporin 11 (AQP11) is a newly described member of the aquaporins family. Aquaporin-11 (AQP-11) has been identified with unusual pore-forming NPA (asparagine-proline-alanine) boxes. AQP-11 presents a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit, contains four pores1. There are two subfamilies: the aquaporins, which transport only water and the aquaglyceroporins, which transport glycerol, urea, and other small solutes in addition to water2.
Aquaporins and aquaglyceroporins are ubiquitously expressed, including in the plasma membrane of renal epithelia, brain astrocytes, and red blood cells3. AQP-11 is expressed in several tissues including testis, kidney, liver, and brain. In the brain, AQP11 is found in Purkinje cells, hippocampal neurons of CA1 and CA2, and cerebral cortical neurons4. In the kidney AQP-11 has a central role in vesicular homeostasis as demonstrated in experiments using AQP-11 knockout mice which display growth retardation and progressively die before weaning. The cause of death seems to be advanced renal failure5.
- 应用类型
- WB
- 免疫原
- Q8CHM1
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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