- 中文名称
NaV1.1抗体
- 英文名字
- NaV1.1 Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1393
- 产品报价
- ￥3025/25 ul
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
Voltage-gated sodium channels (Nav) are essential for the generation of action potentials and for cell excitability1. Nav channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine Nav a subunits have been cloned and named Nav1.1-Nav1.94-5. The Nav channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7) and TTX-resistant (Nav1.5, Nav1.8 and Nav1.9)2-3. Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Na+ channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas Na+ channels in adult skeletal muscle have only the β1 subunit6,7.
Nav1.1 is a highly tetrodotoxin-sensitive channel and is broadly expressed in neurons7.
Mutations in NaV1.1 are associated with at least two forms of epilepsy. Gain-of-function missense mutations are a primary cause of generalized epilepsy with febrile seizures plus (GEFS+). Loss-of-function mutations cause severe myoclonic epilepsy of infancy (SMEI) 8,9.
- 应用类型
- WB
- 免疫原
- P04774
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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