- 中文名称
TRPV5抗体
- 英文名字
- TRPV5 Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1348
- 产品报价
- ￥4125/50 ul
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1 According to IUPHAR the TRP family comprises of three main subfamilies on the basis of sequence homology; TRPC, TRPM and TRPV (to date, three extra subfamilies are considered to belong to the TRP family; the TRPA, TRPML, and TRPP).1-4 The TRPV subfamily consists of six members, TRPV1-6.5
TRPV5 (ECaC) and TRPV6 (CaT1) are unique members of the TRP family. Both are epithelial Ca2+ channels, form constitutively open channels, share high degree of homology (about 66%) with differences in the N and C-terminus. TRPV6 and TRPV5 are expressed in a 1,25-dihydroxyvitamin D3 dependent manner. In contrast to other members of the TRP family, TRPV5 and TRPV6 are highly Ca2+ selective and are expressed in Ca2+ transporting epithelia where they are assumed to have an important role in Ca2+ reabsorption.6,7 TRPV5 is preferentially expressed in kidney.
Alomone Labs is pleased to offer a highly specific antibody directed against an intracellular epitope in the C-terminus of the human TRPV5. Anti-TRPV5 antibody (#AG1348) can be used in western blot analysis, immunocytochemical and immunohistochemical applications. It has been designed to recognize TRPV5 from human and rat samples.
- 应用类型
- WB
- 免疫原
- Q8NDW5
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
-
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