- 中文名称
Anoctamin-2 (胞外)抗体
- 英文名字
- Anoctamin-2 (extracellular) Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1307
- 产品报价
- ￥4125/50 ul
- 产品说明书
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- 购买方式
- 产品新闻
- 背景资料
- Anoctamin (ANO, or TMEM16) is a family of membrane proteins which includes 10 members. This family is named so because these channels selective to ANions and have eight (OCT) transmembrane domains. Also, these channels are subject to glycosylation in their extracellular loops and have both intracellular N- and C-termini1. Members of this family are expressed in a broad range of different organisms ranging from mammals, flies, worms, plants as well as yeast1. Alternative splicing is known to affect these channels and regarding their oligomerization state, homedimerization has been observed although when heterologously expressed, these channels may hetero oligomerize2.
Ano1 (or TMEM16A, DOG1 and others) the first member to be identified was found to be a Ca2+-activated Cl- channel3-5 therefore other members are likely to also be Cl- channels. These channels are expressed in many different tissues: bronchiolar epithelial cells, pancreatic acinar cells, proximal kidney tubule epithelium, retina, dorsal root ganglia and submandibular gland1. In fact, Ano1 gained a lot of attention as its activation may serve as a therapeutic treatment for cystic fibrosis since it is also expressed in the airways6. These Ca2+-activated Cl- channels are believed to play a role in development as knock out of Ano1 in mice causes abnormal development of the trachea7. Ano2 (TMEM16B) has been shown to mediate Ca2+-activated Cl- current in olfactory epithelium and photoreceptor synapses2,8,9.
Although relatively newly discovered channels, they are being discovered in many medical indications. Ano1 has become a marker in gastrointestinal tumors as its expression is significantly upregulated in such tumors10,11. Similarly, Ano1 is also highly expressed other carcinomas12,13.
Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of mouse Anoctamin 2 channel. Anti-Anoctamin-2 (extracellular) antibody (#AG1307) can be used in western blot and immunohistochemical applications and has been designed to recognize Anoctamin-2 channel from mouse, rat and human samples.
- 应用类型
- WB
- 免疫原
- Q8CFW1
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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