- 中文名称
GABA (A) alpha3 Receptor (胞外)抗体
- 英文名字
- GABA (A) alpha3 Receptor (extracellular) Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1277
- 产品报价
- ￥4125/50 ul
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
The neurotransmitter GABA (γ-aminobutiric acid) inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells.1 Binding of GABA to its GABAA receptor results in conformational changes that open a Cl- channel, producing an increase in membrane conductance that results in inhibition of neural activity.2
There are two major types of GABA receptors: the ionotropic GABAA receptors (GABAAR) and the metabotropic GABAB receptors (GABABR). GABAARs belong to the ligand-gated ion channel superfamily.1,2
GABAARs are heteropentamers, in which all five subunits contribute to formation of the pore. Eight subunit isoforms have been cloned: α, β, γ, δ, ε, π, θ, and ρ.1 Six α subunits isoforms (α1-α6) have been shown to exist in mammals.
In most cases, the native GABAA receptors consist of 2α, 2β, and 1γ subunits.
The α3-subunit is highly expressed during development (along with α2 and α5) and then declines in adulthood, where the α1-subunit becomes predominant. The failure to complete this switch could be a major predispositional factor in the development of temporal lobe epilepsy.3
- 应用类型
- WB
- 免疫原
- P34903
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
-
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