- 中文名称
GABA (A) alpha6 Receptor (胞外)抗体
- 英文名字
- GABA (A) alpha6 Receptor (extracellular) Antibody
- 供应商
- Abgent
- 产品货号
- A-AG1276
- 产品报价
- ￥4125/50 ul
- 产品说明书
- 点击查看
- 购买方式
- 产品新闻
- 背景资料
- GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake and metabolism occur in the nervous system.1
The GABA transmitter interacts with two major types of receptors: ionotropic GABA(A) and the metabotropic GABA(B) receptors. The GABA(A) receptor belongs to the ligand gated ion channel superfamily.2
The GABA(A) R, is a heteropentamer, with all of its five subunits contributing to the pore formation.
To date, eight subunit isoforms were cloned: α, β, γ, δ, ε, π, θ, and ρ.1 Six α subunit isoforms were described to exist in mammals (α1-α6). The native GABA(A) receptor, in most cases, consists of 2α, 2β and 1γ subunit. The α subunit is the most common subunit and is expressed ubiquitously.
It determines the affinities for allosteric ligands shown by GABA(A)R.
A possible role for the GABA(A) receptors in alcohol action has been derived from animal studies, in vitro cell models and human research which suggested an important role for GABA(A) α6 along with β2, α1 and γ2, in alcohol related phenotypes.3
In Canavan disease (inherited leukodystrophy), low level of expression of GABA(A) α6 was reported.4
Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of rat GABA(A) α6 Receptor. The Anti-GABA(A) α6 Receptor (extracellular) antibody (#AG1276) can be used for western blot analysis and Immunohistochemical applications. It has been designed to recognize GABA(A) α6 Receptor from rat, mouse and human samples.
- 应用类型
- WB
- 免疫原
- P30191
- 来源宿主
- 反应性
- 保存建议
- 其他
- ABGENT
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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